Gongjin-dan’s Effect on Chronic Fatigue

Abstract

This study scientifically examines the therapeutic effects and mechanisms of Gongjin-dan, a traditional Korean herbal formula, in alleviating chronic fatigue. A study conducted at Daejeon University Korean Medicine Hospital found that the group administered Gongjin-dan experienced a 1.5-fold increase in fatigue endurance time, a more than 50% reduction in stress hormone secretion, a 50–70% decrease in abnormally elevated serotonin levels, and reduced accumulation of exercise-related fatigue substances. These results suggest that Gongjin-dan has anti-fatigue effects and may help mitigate brain dysfunctions associated with chronic fatigue, such as memory impairment, decreased concentration, and sleep disturbances.

Introduction

Chronic fatigue syndrome (CFS) has emerged as a significant health concern, characterized by cognitive impairments such as memory and concentration deficits, reduced motivation, and sleep disturbances, often leading to decreased quality of life. In traditional Korean medicine, Gongjin-dan has long been used to restore immune function and alleviate chronic fatigue. Ancient texts such as Dongui Bogam document its role in enhancing vitality and balancing the body's organ systems. This study aims to provide scientific evidence supporting these traditional claims.

Methods

A clinical study was conducted at Daejeon University Korean Medicine Hospital to evaluate the effects of Gongjin-dan on chronic fatigue patients.

• Participants: Individuals suffering from chronic fatigue symptoms

• Study Design: Comparative analysis between the Gongjin-dan treatment group and a control group

• Key Evaluation Metrics:

  • Fatigue endurance time

  • Blood levels of stress hormones

  • Changes in serotonin levels

  • Accumulation of exercise-induced fatigue substances

Results

The results demonstrated significant differences between the treatment and control groups:

1. Increased Fatigue Endurance: Participants who took Gongjin-dan showed a 1.5-fold increase in their ability to endure fatigue.

2. Reduction in Stress Hormones: Stress hormone secretion decreased by over 50% in the treatment group.

3. Normalization of Serotonin Levels: Excessively high serotonin levels, commonly observed in chronic fatigue patients, were reduced by 50–70% in the Gongjin-dan group.

4. Improved Exercise Recovery: The accumulation of fatigue-related substances after physical activity was either reduced or maintained within normal levels.

Discussion

This study provides scientific validation of Gongjin-dan’s efficacy in alleviating chronic fatigue and its physiological mechanisms.

• Anti-Fatigue Properties: The extended fatigue endurance time and reduced stress hormone levels indicate that Gongjin-dan may help improve both physical and mental health in chronic fatigue patients.

• Neurotransmitter Regulation: The normalization of serotonin levels suggests that Gongjin-dan may counteract brain dysfunctions associated with chronic fatigue, potentially improving concentration and memory.

• Enhanced Post-Exercise Recovery: The reduction in fatigue-related substances after exercise implies that Gongjin-dan may facilitate faster physical recovery and improve daily functioning for individuals suffering from chronic fatigue.

Conclusion

This study scientifically verifies the anti-fatigue effects of Gongjin-dan, supporting the traditional claims of its therapeutic properties. The findings suggest that Gongjin-dan may enhance cognitive function, immune recovery, and overall well-being in individuals with chronic fatigue. Further large-scale clinical trials are warranted to explore its full potential and refine its applications in modern medicine.

References

1. Research data from Daejeon University Korean Medicine Hospital (Lead researcher: Professor Chang-Kyu Son)

2. Traditional Korean medical literature, including Dongui Bogam